Sodium valproate in the treatment of cerebellar disorders.
نویسندگان
چکیده
Because of the high concentrations of gamma-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.
منابع مشابه
The Effects of Sodium Valproate in Improving Developmental Delay in Seizure-Free Children with Abnormal Electroencephalography
Background: Developmental delay is one of the most common problems of children referred to pediatric neurology clinics. While there are reports on rehabilitation and its effects, limited studies are available to delineate pharmacotherapy of such children. Because many children with developmental delay have abnormal findings in electroencephalography, we aimed to treat a group of these children,...
متن کاملImmunological Correlates of Adult Onset Idiopathic Generalized Tonic-clonic Epilepsy before and after Sodium Valproate Treatment
Objective: To investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among Iranian patients before and after sodium valproate treatment. Patients and Methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. Serum antinuclear antibodies (ANA), anti-cardiolipin antibodies (aCL), a...
متن کاملThe effect of sodium valproate on sex hormones in male rats
Background & Aim: Sodium valproate is one of the most common antiepileptic drugs used in the first line of treatment for epilepsy, bipolar disorder, mood disorders, and more recently, as an anticancer drug. The occurrence of seizures and the use of Sodium valproate both have sexual and hormonal side effects and ultimately cause infertility in males. In previous studies, the definitive effects o...
متن کاملAn Investigation and Comparison of the Effect of Sodium Valproate on Electrophysiological Specificities of the Epileptic and Bipolar Patients
Objective: Patients with epilepsy and with bipolar mood disorder usually are treated with anticonvulsant drugs; and this is due to similar neurological, electrophysiological, and chemical mechanisms, by which both of the disorders can be described. However, these two types of disorders are classified differently under the titles of either neurological or psychiatric disorders. The aim of this ...
متن کاملP-15: Effect of Consumption of Korean Red Ginseng and Sodium Valproate on Apoptosis of Spermatogenic Cells and Sperm Quality in Pilockarpin-Induced Epilepsy Rat Model
Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...
متن کاملCOMPARISON OF THE EFFECT OF SODIUM VALPROATE AND LEVETIRACETAM ON THE PREVENTION OF MIGRAINE HEADACHES: A PROSPECTIVE STUDY
Background & Aims: Preventive treatment of migraine headaches is performed after careful and complete examination of the number and quality of headaches in the patient to improve the patient's quality of life and avoid unpleasant side effects. This study was conducted to evaluate the efficacy of two drugs of levetiracetam and sodium valproate on preventive treatment of migraine headaches. Mate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
دوره 6 4 شماره
صفحات -
تاریخ انتشار 1979